Contributing Teams
AMP PD Sponsored: Technome
Technome is a technology consulting firm specializing in planning and designing health research information systems and preparing high quality data for effective consumption by the research community.
Dr. Victoria Dardov leads data generation at Technome. With a biological focus on neurodegenerative diseases, Dr. Dardov’s expertise in proteomics, data analysis and visualization, and disease modeling has enabled her to make data and analysis tools accessible to clinicians and researchers at all levels of expertise.
For information, contact: Victoria Dardov, PhD (https://amp-pd.org/spotlights/dardov)
Team Members
AMP PD Sponsored: PPMI RNA Data Working Group
The PPMI RNA Data Working Group was made up of the Van Keuren-Jensen Lab at TGen and the Craig Lab at UCS. This team was responsible for the processing and analysis of the PPMI RNAseq data as described here: https://www.nature.com/articles/s43587-021-00088-6. The same group led the effort to integrate the PPMI RNAseq data into AMP-PD and was instrumental in setting up the processing and analysis of the entirety of AMP-PD RNAseq data.
For information, contact: Kendall Van Keuren-Jensen and David Craig
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AMP PD Sponsored: Craig Lab, Department of Translational Genomics, Keck School of Medicine of USC
The Craig Lab at USC has been heavily involved in AMP-PD, beginning with the PPMI project and continues to be a valuable contributing member of the community. Their expertise is in RNAseq analysis and visualization as exemplified in the AMP-PD RNA-Seq Explorer, found here on Terra.
Mission Statement: We are deeply committed to excellence in translational genomics research, bringing to bear vast experience and expertise in molecular genetics, genome science, biomedical informatics, translational science, and molecular medicine. Our ultimate goal is to serve the Keck community by bridging basic and clinical research through discovery and validation of novel diagnostics and therapeutics for earlier diagnosis and smarter treatments.
For information, contact: David Craig, PhD (http://dtg.usc.edu)
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Research Community: The Neurochemistry Lab of Amsterdam UMC
At Amsterdam UMC we train thousands of young people to become doctors, specialists or nurses. Amsterdam UMC has eight research institutes. The researchers affiliated with these are internationally among the top in medical scientific research. Through the cooperation of Amsterdam UMC with other hospitals in the region of Noord-Holland and Flevoland, the patient receives the highest quality of care in the right place. At Amsterdam UMC we offer excellent academic patient care, state-of-the-art scientific research and top-level education and training.
For information, contact: Marta del Campo and Charlotte Teunissen
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Research Community: Morris Lab and PD Dementia collaborators
The Morris Lab is based at the Department of Clinical and Movement Neurosciences, University College London. Its focus is on the translational, genetic and pathological aspects of Parkinson’s disease and atypical parkinsonisms. The team collaborates actively with the Global Parkinson’s Genetics Program (GP2).
For information, contact: Professor Huw R. Morris
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Research Community: International Parkinson’s Disease Genomics Consortium (IPDGC)
In 2009 a worldwide collaboration was started between genetic scientists from the United States, United Kingdom, The Netherlands, France and Germany, forming the International Parkinson’s Disease Genomics Consortium (IPDGC). The initial goal encompassed the performance of a GWAS, reaching a sample size allowing for sufficient power to identify novel PD risk factors. With more than 150 members and over 60 publications, the consortium has proven to be of great value to the PD research community by the identification of both Mendelian and risk genes important for PD. For more information check out our decade IPDGC manuscript in Journal of Parkinson's disease here
For information, contact: Mike Nalls, PhD
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Research Community: Healthy Brains Healthy Lives (HBHL)
Healthy Brains, Healthy Lives (HBHL) is an interdisciplinary program, built on McGill's global leadership in interdisciplinary neuroscience, that uses big data analysis to reveal the fundamental mechanisms underlying normal brain function and brain disorders. HBHL aims to accelerate translational discoveries and create a global centre of excellence in neuroinformatics at McGill to improve brain health in Canada and around the world.
For information, contact: Eric Yu
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Research Community: NIA Laboratory of Neurogenetics
The Molecular Genetics Section (MGS) of the Laboratory of Neurogenetics, led by Dr. Andrew Singleton, works on the identification of genetic variants that cause and contribute to both simple and complex neurological diseases. The MGS works across varied neurodegenerative diseases including most prominently Parkinson's disease but also ataxia, dementia with Lewy bodies, frontotemporal dementia, and rare orphan syndromes.
The MGS uses a combination of state of the art genetics and genomics approaches. Further the MGS has acted as a catalyst for the creation of large collaborative consortia aimed at dissecting the genetic basis of common complex diseases.
The Neuromuscular Diseases Research Section of the Laboratory of Neurogenetics, led by Dr. Bryan J. Traynor, is best known for its work to understand the genetic etiology of amyotrophic lateral sclerosis (also known as Lou Gehrig's disease) and frontotemporal dementia. In 2011, he led the international consortium that identified a pathogenic hexanucleotide repeat expansion in the C9orf72 gene as the underlying gene variant in a large proportion of amyotrophic lateral sclerosis and frontotemporal dementia (Neuron 2011).
Other notable achievements of Dr. Traynor's laboratory include the first genome-wide association study of ALS (Lancet Neuro 2007); identification of the chromosome 9p21 association signal for ALS in the Finnish founder population (Lancet Neuro 2010); the identification of the C9orf72 repeat expansion in patients clinically diagnosed with Alzheimer’s disease (NEJM 2012); and the description of variations in the VCP, MATR3, CHCHD10, HTT and SPTLC1 genes as causes of familial ALS and FTD (Neuron 2010, Nature Neuroscience 2014, Brain 2014, Neuron 2018, Neuron 2021, JAMA Neurology 2021).
For information, contact: S. Bandres‑Ciga and S. Saez-Atienzar
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